A Novel Role of IL-17+ Cell Subsets in Ross River Virus-Induced Arthritic Disease
September 2017
in “
Griffith Research Online (Griffith University, Queensland, Australia)
”
TLDR Blocking IL-17 can reduce joint inflammation in Ross River Virus infections.
The study investigated the role of IL-17+ cell subsets in Ross River Virus (RRV)-induced joint inflammation using a mouse model. It identified two distinct subsets of IL-17-producing cells, CD4+ and CD8+ T cells, in the joints of infected mice. The research demonstrated that blocking IL-17A with a monoclonal antibody reduced disease severity without affecting cell subsets or viral load, but decreased IFN-[gamma] levels. Additionally, targeting the IL-17A/F heterodimer also reduced disease severity, suggesting both isoforms contribute to RRV pathogenesis. The findings indicated that IL-17+ T cell subsets played a role in joint inflammation, and targeting IL-17 could be a promising therapeutic approach for alphaviral infections.
