A Novel Marker of Tissue Junctions, Collagen XXII

    May 2004 in “ Journal of Biological Chemistry ”
    Manuel Koch, Jörg Schulze, Uwe Hansen, Todd Ashwodt, Douglas R. Keene, William J. Brunken, Robert E. Burgeson, Peter Brückner, Leena Bruckner‐Tuderman
    TLDR Collagen XXII is a marker for tissue junctions, aiding in structural integrity and found in muscles, heart, skin, and arthritic joints.
    The study identified collagen XXII as a novel marker of tissue junctions, particularly in muscle, cartilage, heart, and skin, with specific localization at sites like myotendinous junctions and around hair follicles. It was part of the FACIT protein family and acted as a cell adhesion ligand, contributing to tissue integrity and cell interactions. Collagen XXII was expressed in skeletal muscle and heart tissues, synthesized by muscle cells, and found in basement membrane zones, indicating its role in structural integrity and force transmission. The study also noted its presence in arthritic joints, suggesting implications for joint disease understanding.
    Discuss this study in the Community →