A functional study of a case of glucagonoma exhibiting typical glucagonoma syndrome

    February 1986 in “ Cancer ”
    Jun Fujita, Yutaka Seino, Hitoshi Ishida, Tomohiko Taminato, Shigeru Matsukura, Takeshi Horio, Sadao Imamura, Atsushi Naito, Takayoshi Tobe, Kiyoyuki Takahashi, Osamu Midorikawa, Hiroo Imura
    TLDR A pancreatic tumor caused high glucagon levels and symptoms, but treatment reduced glucagon and shrank liver tumors.
    A 46-year-old man with a 7-year history of necrolytic migratory erythema and other symptoms such as weight loss, anemia, and hair loss was diagnosed with glucagonoma, a pancreatic tumor. His fasting plasma glucagon levels were extremely high, and further increased with glucose, meals, and arginine, but decreased with somatostatin and insulin-induced hypoglycemia. Imaging revealed a large pancreatic tumor with liver and lymph node metastases. The tumor was surgically removed, but high glucagon levels persisted, leading to treatment with dimethyltriazenoimidazole carboxamide, which reduced glucagon levels and shrank hepatic metastases.
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