A Case of Beau’s Lines at Even Intervals and Onycholysis Caused by Chemotherapy

    January 2009 in “ The Open Dermatology Journal ”
    Tatsuhiko Morioka, Ichiro Kurokawa, Keiichi Yamanaka, Hitomi Sugisaki, Koji Habe, Kenichi Isoda, Hitoshi Mizutani
    TLDR Chemotherapy caused nail grooves and separation, but they healed after treatment stopped.
    A patient with stage IIA diffuse large B-cell lymphoma (DLBCL) underwent six cycles of R-CHOP chemotherapy at 21-day intervals, resulting in the development of Beau’s lines (transverse grooves) on all 20 nails after each cycle. The patient also experienced onycholysis due to cyclophosphamide and doxorubicin treatment. Two months after stopping chemotherapy, the Beau’s lines disappeared.
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