A 5'-upstream region of a bovine keratin 6 gene confers tissue-specific expression and hyperproliferation-related induction in transgenic mice.
May 1995
in “
Proceedings of the National Academy of Sciences
”
TLDR A specific gene region can control targeted and responsive gene expression in mice, useful for skin disorder treatments.
The study investigated the regulatory sequences of the bovine keratin 6 gene, which is known for its complex expression pattern in hair follicles and various stratified epithelia, and its induction during hyperproliferative conditions. Researchers used transgenic mice to test different parts of the keratin 6 gene linked to a beta-galactosidase reporter gene. They found that a 9-kbp fragment from the 5' upstream region could drive both tissue-specific and inducible expression, suggesting its potential use in gene therapy for epidermal hyperproliferative disorders.
