Estrogen Monotherapy for Testosterone Suppression in Gender Diverse Patients
October 2024
in “
Journal of the Endocrine Society
”
This study retrospectively reviewed estrogen monotherapy for testosterone suppression in gender diverse individuals assigned male at birth, specifically focusing on transfeminine patients. Out of 10 patients, 7 transfeminine individuals achieved testosterone suppression with serum estradiol levels over 100 pg/mL, using either injectable or transdermal estrogen formulations. Injectable estradiol valerate (4-6 mg weekly) and transdermal patches (0.2 mg twice weekly to 0.3 mg three times weekly) were effective. The study suggests estrogen monotherapy could be a viable alternative to anti-androgens, though the small sample size is a limitation. Further research is needed to confirm these findings and potentially simplify treatment protocols.