Μελέτη της έκφρασης των δεικτών πολυδυναμικότητας στις ιδιοπαθείς φλεγμονώδεις νόσους του εντέρου

This study investigated the expression patterns of OCT4 and SOX-2 in patients with Crohn's disease (CD) and ulcerative colitis (UC), compared to healthy individuals. It was found that OCT4 protein levels were significantly higher in tissue samples from CD patients than in their blood samples and UC tissue samples. The OCT4 protein was primarily located in the cytoplasm, and only the pseudogenes and the isoform OCT4B1 were detected across all samples. OCT4B1 expression levels were elevated in both tissue and blood samples from CD and UC patients compared to healthy controls. In CD patients, SOX-2 mRNA levels were slightly increased compared to healthy controls. The findings suggested that early developmental cells might be mobilized in peripheral blood due to tissue damage, indicating a potential role in intestinal tract erosion repair.