Μορφογένεση της επιδερμίδας

The study investigated the carbohydrate composition of plasma cell membranes during human epidermal morphogenesis using 152 tibial skin specimens from different gestational age groups (10-23 weeks EGA). It found that specific carbohydrates, such as D-galactose-β-(1,3)-N-acetyl-D-galactosamine, β-D-galactose, α-D-N-acetyl-D-galactosamine, α-D-glucose, and α-D-mannose, showed distinct binding patterns in various epidermal layers, which changed over time and were similar to adult epidermis by 23 weeks EGA. These findings suggested that carbohydrate residues play significant roles in epidermal differentiation and could be important for understanding the pathogenesis and management of skin conditions. However, the mechanisms of synthesis and transport of these molecules remain unclear, and the study's results both align with and contradict previous research, likely due to differences in specimen sources and techniques used.