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Metformin

also Glucophage

Diabetes drug that lowers blood sugar

Metformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polyendocrine metabolic ovarian syndrome, and is sometimes used as an off-label adjunct to lessen the risk of metabolic syndrome in people who take antipsychotic medication. It has been shown to inhibit inflammation, and is not associated with weight gain. Metformin is taken by mouth.

Information, not medical advice. Talk to a licensed doctor or pharmacist before starting or changing a treatment.

Research 10

  1. Robust Metformin Nanosystem Promotes Hair Growth in Androgenetic AlopeciaResearch · 2025 · 5 citations
  2. Topical Metformin Compared with Clobetasol Propionate for Alopecia Areata: Clinical Outcomes from a Comparative Study.PubMed Central · 2026
  3. Hair regrowth in 2 patients with recalcitrant central centrifugal cicatricial alopecia after use of topical metforminJAAD Case Reports · 2020 · 52 citations
  4. A Systematic Review on Clinical Evidence for Topical Metformin: Old Medication With New ApplicationHealth Science Reports · 2024 · 9 citations
  5. Efficacy of metformin in human single hair fibre by ATR-FTIR spectroscopy coupled with statistical analysisJournal of Pharmaceutical and Biomedical Analysis · 2016 · 11 citations
  6. New onset of alopecia in a young woman with end-stage renal diseaseClinical Kidney Journal · 2008 · 2 citations
  7. Metformin Promotes the Hair-Inductive Activity of Three-Dimensional Aggregates of Epidermal and Dermal Cells Self-Assembled in vitroSkin Pharmacology and Physiology · 2021 · 14 citations
  8. Anti-androgen therapy in polyendocrine metabolic ovary syndrome (PMOS, formerly PCOS): efficacy, safety, and phenotype-oriented clinical decision-makingJournal of Ovarian Research · 2026
  9. Stimulation of Hair Growth by Small Molecules that Activate AutophagyCell reports · 2019 · 154 citations
  10. Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial AlopeciaJAMA Dermatology · 2024 · 25 citations
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