The Hair Follicle as a Dynamic Miniorgan
February 2009
in “Current Biology”
TLDR Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
The 2009 study "The Hair Follicle as a Dynamic Miniorgan" explored the complex biology of hair follicles, which are responsible for producing hair shafts. The study emphasized the importance of mouse models in understanding hair follicle biology, providing insights into organ induction, morphogenesis, regeneration, pigment and stem cell biology, and cell proliferation, migration, and apoptosis. The study also detailed the process of hair follicle development, involving three phases: induction, organogenesis, and cytodifferentiation, and highlighted the role of Wnt/ß-catenin signalling in determining hair follicle fate. The document also discussed the hair cycle, the role of various molecules in this process, and the role of stem cells in hair follicle maintenance and regeneration. The study concluded that the hair follicle is a clinically relevant model for studying principles of developmental, stem cell, and tumour biology, tissue regeneration, and the control of cell growth, migration, death, and differentiation.
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research The Hair Follicle as an Estrogen Target and Source
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Mice without the vitamin D receptor gene lose hair due to disrupted hair follicle cycles.
research Characterization and isolation of stem cell-enriched human hair follicle bulge cells
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research Runx3 is involved in hair shape determination
Runx3 helps determine hair shape.
research Melanocyte Stem Cell Maintenance and Hair Graying
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research Hair Follicle Pigmentation
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research Molecular principles of hair follicle induction and morphogenesis
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research Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: annotated tables
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CDP is crucial for lung and hair follicle cell development.
research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells
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research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis
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research The Biology of Hair Follicles
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research The Hair Follicle as a Dynamic Miniorgan
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