Review of Human Hair Follicle Biology: Dynamics of Niches and Stem Cell Regulation for Possible Therapeutic Hair Stimulation for Plastic Surgeons
October 2018
in “Aesthetic Plastic Surgery”
TLDR Understanding hair follicle biology and stem cell control could lead to new hair loss treatments.
The document from 2018 reviews the biology of human hair follicles, particularly the role of stem cell niches in hair growth cycles and the potential for hair regeneration. It discusses the epidemiology and pathophysiology of androgenetic alopecia (AGA), female-pattern hair loss (FPHL), and chronic telogen effluvium (CTE), as well as current treatment options like minoxidil and finasteride. The review also examines the use of platelet-rich plasma (PRP) and adipose tissue in treating AGA, noting some positive clinical trial results but calling for further research. It emphasizes the need to better understand the molecular controls of follicle induction and morphogenesis to develop effective hair loss treatments, while cautioning against directly applying animal model findings to human hair follicle development. The document concludes by underscoring the potential for innovative therapies based on recent insights into hair follicle biology and stem cell regulation.
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