Repeal and Replace: Adipocyte Regeneration in Wound Repair
April 2017
in “Cell Stem Cell”
TLDR Skin wounds can create fat cells that help regenerate hair follicles, with BMP signaling playing a crucial role in this process.
In a study conducted by Plikus et al. in 2017, it was found that myofibroblasts can generate lipid-filled adipocytes in large skin wounds that regenerate hair follicles, suggesting a new source of adipogenic progenitor cells. This discovery adds to the understanding of dermal mesenchymal cell heterogeneity. The study also identified several molecular changes during wound repair, including BMP2 and BMP4 expression. It was found that activation of BMP signaling in myofibroblasts is essential for the formation of mature adipocytes after repair of large wounds. The study further supports the ability of dermal adipocyte lineage cells to respond to signals derived from hair follicles. This research could have implications for adipose regeneration in the skin and regulation in other adipose depots.
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Cited in this study
research Regeneration of fat cells from myofibroblasts during wound healing
Some wound-healing cells can turn into fat cells around new hair growth in mice.
research Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis
PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.
research Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog
Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.
research Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors
Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.
research Intradermal adipocytes mediate fibroblast recruitment during skin wound healing
Fat cells help recruit healing cells and build skin structure during wound healing.
research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling
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research Repeal and Replace: Adipocyte Regeneration in Wound Repair
Skin wounds can create fat cells that help regenerate hair follicles, with BMP signaling playing a crucial role in this process.