Hair Regeneration and Rejuvenation: Pipeline of Medical and Technical Strategies
January 2022
in “Stem cell biology and regenerative medicine”
TLDR New treatments are needed for hair loss, and cell therapies might reverse hair thinning.
The document reviews the development of medical and technical strategies for treating androgenetic alopecia, a prevalent type of hair loss. It notes that while adult mouse dermal follicular cells have shown the ability to generate new hair, no cell therapy for this condition is currently available in the market. The potential of hair follicle dermal papilla and dermal sheath cells to create new hair follicles is highlighted. However, early 2000s clinical trials by Intercytex and Aderans Research Institute, while showing some hair neogenesis, did not meet expected cosmetic efficacy. The current focus is on rejuvenating existing, miniaturising hair follicles rather than regenerating them. The document concludes that alternative treatments for androgenetic alopecia are needed, and cell therapies using dermal papilla and dermal sheath cells could potentially reverse hair follicle miniaturisation.
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