Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing
April 2022
in “Frontiers in Medicine”
TLDR Hair and skin healing involve complex cell interactions controlled by specific molecules and pathways, and hair follicle cells can help repair skin wounds.
The document discusses the role of epithelial-mesenchymal interactions (EMIs) in hair follicle regeneration and skin wound healing. EMIs control cellular interactions and involve molecules like growth factors and hormones. Key pathways in hair development and wound healing include Sonic hedgehog (SHH), wingless (Wnt), bone morphogenetic protein (BMP), and fibroblast growth factor (FGF). Dermal papilla in hair follicles secrete components like epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I), which regulate hair growth. Hair follicles also contribute to skin wound healing post-injury through EMI. Transplanting hair follicle progenitor cells in patients with extensive skin burns can enhance angiogenesis, regulate the inflammatory response, speed up wound healing, and improve skin regeneration. The document also notes the decrease of dermal papillae in patients with androgenetic alopecia and the importance of maintaining a balance of hair follicle dermal stem cells.
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