Twist2 Contributes to Skin Regeneration and Hair Follicle Formation in Mouse Fetuses
May 2024
in “
Scientific reports
”
TLDR Twist2 is essential for scarless skin healing and hair growth in mouse fetuses.
The study investigates the role of Twist2 in skin regeneration and hair follicle formation in mouse fetuses. Twist2 expression was found to be upregulated in the dermis of embryonic day 13 (E13) wound margins but downregulated in E15 and E17 wounds. Knockdown of Twist2 on E13 resulted in visible marks, inhibited regeneration, and defective follicle formation. Twist2-knockdown dermal fibroblasts lacked the ability to undifferentiate, and Twist2 hetero knockout mice formed visible scars even on E13. These findings suggest that Twist2 is crucial for scarless wound healing and hair follicle regeneration, potentially guiding therapeutic strategies to reduce scarring and promote hair growth.
View this study on nature.com →
Cited in this study
5 / resultsresearch Downregulation of Lhx2 Markedly Impairs Wound Healing in Mouse Fetus
Turning off the Lhx2 gene in mouse embryos leads to slower wound healing and scars.
research Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds
The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.
research Defining the Identity of Mouse Embryonic Dermal Fibroblasts
Researchers identified specific genes that are important for mouse skin cell development and healing.
research Wound Healing and Skin Regeneration
Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.
research Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation
Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.
Related
1 / resultsresearch Regeneration of Hair Follicles Is Modulated by Flightless I (Flii) in a Rodent Vibrissa Model
Flightless I protein affects hair growth, with low levels delaying it and high levels increasing hair length in rodents.