Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Three studies conducted 8 years ago collectively found that high Nesfatin-1 (N1) and low Vitamin D (VD) levels may be associated with increased blood pressure and heart rate in women with Polycystic Ovary Syndrome (PCOS). The first study involved 60 women with PCOS and 30 healthy women, while the second and third studies involved 54 and 48 PCOS patients respectively, with corresponding control groups. Across all studies, women with PCOS had significantly higher N1 levels, systolic and diastolic blood pressure, and heart rate, but lower VD levels compared to the control groups. N1 showed a positive correlation with Body Mass Index, insulin resistance, inflammation, and luteinizing hormone, while VD levels were negatively correlated with insulin resistance and luteinizing hormone. These findings suggest that both high N1 and low VD levels may contribute to the development of hypertension in PCOS patients.