Effects of porcine acellular dermal matrix treatment on wound healing and scar formation: Role of Jag1 expression in epidermal stem cells

The document from January 2, 2018, summarizes a study that explored the impact of Jag1 expression in epidermal stem cells (ESCs) on wound healing and scar formation, and how porcine acellular dermal matrix (ADM) treatment influences this process. The study found that Jag1 plays a critical role in regulating the differentiation of ESCs into myofibroblasts (MFB), which are associated with scar formation. In vivo experiments showed that knocking out Jag1 in ESCs led to delayed wound healing and increased scar formation, while porcine ADM treatment promoted faster wound closure and reduced scarring. This treatment worked by enhancing the Notch/Jagged1 signaling pathway in ESCs, as indicated by increased expression of Jag1, Notch1, and Hes1 in wound tissues. The study involved 10 mice per experimental group and demonstrated statistical significance with P<0.05. These findings suggest that targeting Jag1 expression in ESCs and using porcine ADM treatment could be effective strategies for improving wound healing and minimizing scar formation.