Association of follicle-stimulating hormone receptor gene ser680 asn (rs6166) polymorphism with polycystic ovarian syndrome

The study examined the relationship between the Ser680Asn (rs6166) polymorphism in the follicle-stimulating hormone receptor (FSHR) gene and polycystic ovarian syndrome (PCOS) in 204 women with PCOS and 204 healthy controls. It found that the A allele and the AA genotype of the FSHR gene were significantly more common in women with PCOS, suggesting a strong association with the condition. Women with the AA genotype also had higher body mass index (BMI), luteinizing hormone (LH) levels, and LH/FSH ratios, while those with the GG genotype had increased basal FSH levels and signs of insulin resistance. The study concluded that the FSHR Ser680Asn polymorphism is linked to PCOS and could potentially be used as a biomarker to assess the risk of developing PCOS in the given population.