Are hair follicle stem cells promising candidates for wound healing?
January 2019
in “Expert Opinion on Biological Therapy”
TLDR Hair follicle stem cells are promising for wound healing but require more research for safe clinical use.
The document reviews the potential of hair follicle stem cells (HFSCs) for wound healing, highlighting their ability to regenerate and differentiate into various cell types that contribute to hair growth and wound repair. It discusses the role of HFSCs in promoting wound closure through re-epithelialization and angiogenesis, and the importance of the Wnt signaling pathway in hair follicle regeneration and wound repair. The review also addresses the challenges in using HFSCs clinically, such as the need for a deeper understanding of human HFSCs, differences in stem cell markers between humans and animals, and the risk of tumorigenesis associated with Wnt signaling activation. The document concludes that while HFSCs are promising for wound healing, particularly in difficult-to-heal wounds, further research is needed to ensure their safe and effective use in clinical practice.
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