862 Defining the molecular signature of the hair follicle dermal sheath and its functional requirement for hair cycle progression during catagen
May 2017
in “Journal of Investigative Dermatology”
TLDR The hair follicle dermal sheath is essential for hair shedding and needs to communicate with the outer root sheath for normal hair growth cycles.
The document presents a study that aimed to define the molecular signature of the hair follicle dermal sheath (DS) and its role in hair cycle progression during catagen. The researchers co-isolated DS, dermal papilla (DP), and dermal fibroblasts to identify gene expression profiles through RNA sequencing. They discovered a unique DS gene expression signature, suggesting potential structural and signaling roles for the DS in hair follicle support and regulation. Using the DS signature gene aggrecan (Acan) for inducible targeting, they created a specific system to manipulate the DS. Conditional cell ablation with the cytotoxic DTA system revealed that the DS is essential for outer root sheath regression at the onset of catagen, indicating a need for DS/epithelial cross-talk during normal hair follicle cycling. This study assigns the DS as a crucial hair follicle niche component, prompting further investigation into its functions for hair follicle activities.
View this study on jidonline.org →
Related
research Activation of β-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth
Activating β-catenin in certain skin cells speeds up hair growth in mice.
research Dermal sheath cells contribute to postnatal hair follicle growth and cycling
Skin sheath cells help in hair growth and renewal after birth.
research 693 Dermal papilla-derived Wnt ligands are required for adult hair follicle growth
Wnt ligands, produced by dermal papilla cells, are essential for adult hair growth and regeneration.
research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type
Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.
research An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation.
Estrogen affects hair growth and skin cell multiplication.