477 Dietary fat- and obesity-sensitive dermal adipocyte PKCβ induction and inflammation cross-talk

The document presents several abstracts from a journal, but the specific abstract requested for summarization discusses the role of protein kinase C beta (PKCβ) in diet- and obesity-induced changes in dermal adipocytes and their impact on skin health. The study found that a high-fat diet strongly induces the expression of PKCβ and inflammatory markers in adipocytes in a time-dependent manner. PKCβ deficiency was associated with improvements in dermal adipocyte inflammation, as well as the texture and density of skin hair. The research suggests that PKCβ is a key transducer of dietary lipids and plays a critical role in modulating the dermal inflammatory microenvironment. The study also mentions the generation of a floxed PKCβ mouse model to further investigate the adipose-specific contributions of the diet-adipocyte PKCβ/inflammation axis to immune responses, wound healing, scarring, and hair-follicle growth. The number of participants or subjects in the study is not mentioned in the abstract.