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- Featured Community Post
FCE 28260: A Forgotten 5α-Reductase Inhibition
FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
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5.5 months (Min 2 times /fin 1.25 1 time) daily //derma 1 every week some supplement and Sometimes I use ketoquinazole shampoo The real results from the beginning of the tenth image. 23 y
Progress Pictures The user experienced improved hair growth using Minoxidil twice daily, finasteride 1.25mg once daily, weekly dermarolling, supplements, and occasional ketoconazole shampoo for 5.5 months, but noticed hair shedding again after switching types of Minoxidil. Despite returning to the original Minoxidil, the user's hair condition worsened and shedding continued. -
After 11 Years On Finasteride, Unfortunately, Hair Is Starting To Thin Again. Does Hair Simply Get More Sensitive To DHT As You Age?
Finasteride/Dutasteride After 11 years on Finasteride, a user's hair is thinning again, suggesting hair may become more sensitive to DHT with age. They plan to introduce Dutasteride once a week, as they cannot tolerate Minoxidil. -
1.5 years on oral fin and minoxidil
Progress Pictures The conversation is about a user's 1.5-year experience using oral finasteride and minoxidil for hair loss. Users discuss the visual improvement, potential side effects, and the normalcy of shedding during treatment. -
5 minutes on finasteride and praying. Is this progress?
Satire The conversation is a satirical discussion about hair loss treatments, with users joking about immediate and exaggerated results from finasteride, dutasteride, and other treatments like microneedling and minoxidil. Some users mock concerns about side effects and the idea of posting rapid progress updates. -
Small progress after 1 year 35m
Progress Pictures A man saw improvement in hair loss after a year using 1mg finasteride daily and minoxidil twice daily, but reduced finasteride due to side effects. He switched to 0.5mg dutasteride daily, topical finasteride twice daily, microneedling weekly, and 2.5mg oral minoxidil, but may stop minoxidil due to chest pains. -
22M. 5 months on 5% min 2x a day. Dermarolling 1-2x a week
Progress Pictures A 22-year-old male has seen improvement in his hair loss after using 5% Minoxidil twice daily and dermarolling once or twice a week for 5 months. He no longer notices a bald spot in photos. -
3 month progress on Minoxidil 5% only.
Is this regrowth? A user is pleased with their hair regrowth after 3 months using Minoxidil 5%. They plan to start Finasteride upon returning home, and others discuss the importance of consistency and patience with hair loss treatments.
Characterization of the mechanical properties of the cortex region of human hair fibers by multiparametric Atomic Force Microscopy mapping
The study investigated the mechanical properties of human hair fibers, specifically the cortex region, using Atomic Force Microscopy (AFM) in force volume mode. The researchers examined both chemically damaged hair (through bleaching) and hair without chemical damage, with and without cosmetic treatment. The results showed a significant decrease in the natural logarithm of Young's modulus (ln(E)) mean value for chemically damaged fibers. The study concluded that AFM provides a more accurate method to evaluate hair damage and the performance of cosmetic treatments, offering detailed information about the hair's structure.
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New in research
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Pilose antler extract promotes hair growth in androgenic alopecia mice by promoting the initial anagen phase
Pilose antler extract helps hair grow in mice with a type of hair loss by speeding up the growth phase.
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A Randomized Controlled, Single-Observer Blinded Study on the Safety and Efficacy of a Combination of 678nm Helmet-Type Low-level Laser Therapy and Topical Minoxidil 5% Versus Topical Minoxidil 5% Alone in the Treatment of Male Androgenetic Alopecia
Using a laser helmet with Minoxidil works better for male hair loss than Minoxidil alone, with no extra side effects.
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The Comparative Effects of Monotherapy with Topical Minoxidil, Oral Finasteride, and Topical Finasteride in Postmenopausal Women with Pattern Hair Loss: A Retrospective Cohort Study
Oral finasteride seems more effective for hair loss in postmenopausal women, but more research is needed.
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Review of: "“Toupee or not Toupee?” Sic (et Non). Social perceptions of Male Pattern Baldness (Androgenetic Alopecia)"
Toupees improved perceived attractiveness, especially by older people, but had little effect on perceived self-assurance and health.
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THE USE OF PLATELET-RICH PLASMA IN THE TREATMENT OF ALOPECIA - A REVIEW OF THE LITERATURE
Platelet-Rich Plasma therapy helps increase hair density and regrowth for some types of hair loss.
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Assessing the Efficacy of Automated Microneedling Monotherapy for Androgenetic Alopecia: A Comparison of 3 Different Depths
Microneedling at a depth of 0.5 mm is the most effective single treatment for hair loss among the tested depths.
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Amino Acids Oral Treatment for the Amelioration of Skin, Hair, and Nails Conditions: An Open-Label Study
Taking an amino acid supplement improved skin, hair, and nail health in women.
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Hair Loss, Body Height and Attractiveness Malus for Men
Men with hair loss are seen as less attractive and shorter, and height is a key factor in attractiveness ratings.
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Persistent Gynecomastia due to Short-term Low-dose Finasteride for Androgenetic Alopecia
A man's breast enlargement from low-dose finasteride for hair loss didn't go away, even with treatment, and might be more common than reported.