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New in community
- Featured Community Post
Research Backed Dutasteride Simulator (Serum/scalp DHT included for all doses)
A Dutasteride Simulator predicts serum dutasteride, serum DHT, and scalp DHT levels using models from research papers. It simulates various dosing schedules to determine steady-state effects and visualizes outcomes, including hair growth-related scalp DHT suppression.
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Taking Dut (90.5mg)+Min (2.5mg). Can you guys tell if there is improvement?
Minoxidil The user is using Dutasteride (90.5mg) and Minoxidil (2.5mg) for hair loss since October 2025 and is seeking feedback on progress by comparing photos from October 2025 and January 2026. They are asking for opinions on whether the treatment shows improvement. -
FDA Policy Shift Explained: What It Actually Means for PP405, VDPHL-01, Breezula and Hair Loss Drug Timelines
Research/Science The FDA policy change may speed up approval for hair loss drugs like PP405, VDPHL-01, and Breezula by potentially eliminating the need for a second confirmatory Phase 3 trial. Approval timelines could be as early as 2028 for some treatments if Phase 3 results are strong. -
7 months into fin, 1.5 months into adding tretinoin to my minoxidil. Hair has continued to worsen entire time.
Progress Pictures The user is experiencing hair thinning despite using finasteride and minoxidil with added tretinoin, and is considering switching to dutasteride. Suggestions include trying dutasteride, oral minoxidil, microneedling, and possibly a hair transplant for better results. -
What to do? (Dog, chest, etc)
General A 43-year-old is experiencing hair thinning and is considering hair loss treatments. They are hesitant to use topical Minoxidil due to its toxicity to pets and oral Finasteride due to concerns about side effects, and are exploring alternatives like topical Finasteride, oral Minoxidil, or microneedling. -
First two picture took on July 7, but started taking med on May 1
Is this regrowth? The user has been using finasteride, minoxidil, and microneedling for hair regrowth over 9.5 months. They plan to continue updating their progress. -
Aged 51 testimony on hair recovery
Treatment A 51-year-old shared their hair recovery journey using finasteride, minoxidil, and dermarolling, noting significant improvement in hairline and temple areas. They emphasize consistency and patience, while another user suggests adding topical kx-826 and melatonin for additional benefits.
New Featured Research
A SIBO-mediated aetiology for a subset of Post-Finasteride Syndrome cases: investigating gut-derived toxins
This theoretical paper suggests a novel gut-centric cause for a subset of Post-Finasteride Syndrome (PFS) cases, which are not fully explained by androgen deprivation. It hypothesizes that a chronic overgrowth of hydrogen sulphide (H₂S)-producing bacteria in the small intestine acts as a systemic mitochondrial toxin. This condition may create a dysbiotic feedback loop that perpetuates the epigenetic silencing initially triggered by finasteride exposure. The paper proposes that this acquired metabolic dysfunction, driven by gut-derived toxins, could explain the persistence of PFS symptoms and highlights the small intestinal microbiome as a potential therapeutic target.
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New in research
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Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments
Spironolactone is effective for treating female hair loss, with new treatments like clascoterone showing promise.
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A SIBO-Mediated Etiology for a Subset of Post-Finasteride Syndrome Cases: Investigating Gut-Derived Toxins
Gut bacteria overgrowth may cause some Post-Finasteride Syndrome symptoms.
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Targeting the Gut Microbiota with Probiotics and Postbiotics: Emerging Strategies Against Alopecia
Modifying gut bacteria with pro- and postbiotics may help treat hair loss.
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The N-K Healing Series: Complete Geometric Restoration for Wounds, Pain, and Burns Using N-K Universal Computer
N-K Geometric Medicine heals wounds, pain, and burns better and faster than current treatments, without side effects.
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The N-K Healing Series: Complete Geometric Restoration for Wounds, Pain, and Burns Using N-K Universal Computer
N-K Geometric Medicine heals wounds, pain, and burns better and faster than current treatments, without side effects.
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Significant Improvement With Ivarmacitinib After Suboptimal Response to Tofacitinib in Severe Alopecia Areata: A Case Report and Literature Review
Ivarmacitinib significantly improved hair regrowth in severe alopecia areata after tofacitinib was less effective.
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Effect of Platelet-Rich Plasma on Hair Follicle Growth in C57BL/6 Mice
Platelet-rich plasma (PRP) speeds up hair growth in mice.
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Development and Evaluation of a Niosome-Integrated Microneedle System for Targeted Follicular Delivery of Ketoconazole in Alopecia Therapy
The new microneedle system improves hair growth in alopecia treatment.
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Comparative Efficacy of Oral Dutasteride and Low, Medium, and High-Dose Oral Minoxidil: A Six-Month Prospective Trichoscopic and Clinical Study
Oral minoxidil improved hair loss more than oral dutasteride.