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All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

Certain nutrients can help keep skin healthy as we age.

The new chemotherapy combination of WP 631 and Epothilone B shows enhanced effectiveness against ovarian cancer but requires more research on its safety.

Protein microarrays are highly sensitive tools useful for disease diagnosis and studying proteins.

Different parts of cells interact at specific areas to control cell functions like energy production and fat storage.

Researchers found two enzymes in Avicennia marina that help produce maslinic acid and corosolic acid, which have medicinal benefits.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Female cuckoo color differences are linked to their unique genes and help avoid male harassment.

Finasteride effectively prevents biofilm formation and treats preformed biofilms, but requires high doses.

Different nail disorders are treated by targeting their specific causes and using appropriate medications or protective measures.

In India, most patients with type 1 autoimmune polyglandular failure show symptoms in a specific order, starting with parathyroid gland issues, then yeast infections, and finally adrenal gland failure.

Effective dandruff treatment requires delivering antifungal agents to the scalp follicular infundibulum.

Mupirocin ointment effectively treats feline acne.

Pregnant women often experience a variety of skin problems, including pigmentation changes and stretch marks.

People in palliative care often have skin problems due to their main illness or other health issues, and treatments focus on comfort and quality of life.

There is no clear recommendation for using selenium in cancer patients; it may be beneficial to correct low selenium levels before treatment.

Treating melasma in men is difficult, especially for the deeper skin layers, and may need more than just topical treatments.

Anticancer drugs are increasingly found in surface waters, and their long-term environmental effects are not well understood, requiring better testing methods.

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Chromium supplements don't improve insulin, hormone levels, or cholesterol in women with PCOS but raise testosterone levels.

A brain-produced steroid causes increased scratching in mice with a skin condition similar to eczema.

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

Cytochrome P-450 enzymes in the skin help break down various substances and could be targeted to treat skin conditions.

Finasteride metabolism varies by age, sex, and P450 inducers, with males processing it faster.

Susan Lee Lindquist was a pioneering biologist who made significant contributions to understanding protein folding and its role in disease.

Alisertib was found to be an effective and tolerable treatment for children with recurrent brain tumors.

Doxazosin mesylate and saw palmetto cause genetic changes in fruit flies.

Certain genetic markers linked to reproductive potential were identified by their impact on a protein's ability to bind to genes.