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Removing part of the vitamin D receptor stops vitamin D from working properly.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

Lecithin organogels could be good for applying drugs to the skin because they are stable, safe, and can improve drug absorption.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Women with epilepsy should be monitored for reproductive issues, which can be caused by epilepsy or its treatments, especially when using valproate.

After menopause, women lose a lot of skin collagen, but estrogen replacement might improve skin health.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Hormonal treatment in transgender women reduces semen quality, but stopping treatment may improve it.

Red ginseng may improve immunity, fatigue, memory, blood circulation, and menopausal symptoms, and is generally safe to consume.

Estrogens and SERMs can help with skin aging, but their safety and effectiveness need more research.

People with polycystic ovary syndrome have a higher chance of having chronic thyroiditis.

Hormonal treatments are effective for severe or persistent acne and should be used with other acne therapies, considering potential side effects.

Sorafenib helps some advanced cancers alone or with other treatments, but not all, and research continues to improve its use.

Lifestyle changes are the main treatment for PCOS, which is a complex condition requiring early management to reduce its health impacts.

Diagnosing PCOS in teenagers is hard because its symptoms often look like normal puberty, and there's a need for better diagnosis methods and agreement on criteria.

Hair loss in elderly women is often caused by various factors, including hormonal changes after menopause.

The document concludes that menopause should be seen as a natural part of aging and managed with personalized care and informed choices.

Testosterone therapy and surgeries like mastectomy improve transgender men's lives and mental health with low risks and high satisfaction.

Skin aging is caused by stem cell damage and can potentially be delayed with treatments like antioxidants and stem cell therapy.

For women with moderate to severe unwanted hair growth or acne, birth control pills are the first choice, with other medications like cyproterone, spironolactone, flutamide, or finasteride as alternatives, and permanent hair removal should be done with electrolysis or laser.

The document concludes that health care providers should offer culturally competent care and more research is needed to improve health outcomes for transgender individuals.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

Amenorrhea, or the absence of periods, should be evaluated by age 15 or within five years of early breast development, and is most commonly caused by conditions like polycystic ovary syndrome and hypothalamic amenorrhea.

Women with mild acne are more likely to have polycystic ovary syndrome (PCOS) than those without acne.

Certain brain hormones and chemicals are linked to the development of Polycystic Ovary Syndrome.

More research is needed on the health effects of hormone therapy for transgender and nonbinary people.

The document says menstruation is important for women's health, discusses menstrual disorders, and suggests personalized treatment options.

In Japan, sex reassignment surgery for gender identity disorder faces challenges and needs better medical support and education.

Most treatments for hair loss in 1997 were not effective for most people, and maintaining hair growth was difficult.