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Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

The hydrogel with a 1:3 ratio of hydroxyethyl cellulose to hyaluronic acid is effective for delivering drugs through the skin to treat acne.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

The article concludes that the wool follicle is a valuable model for studying tissue interactions and has potential for genetic improvements in wool production.

Animals that change color with the seasons mainly do so in response to daylight changes, but climate change is causing camouflage problems that may require evolutionary changes.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.

UV radiation can help sterilize wounds and promote healing but requires careful use to avoid damaging cells.

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Hormonal treatments, including birth control and antiandrogens, can effectively treat acne in women.

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

Targeted cancer therapies often cause skin reactions, so dermatologists must manage these effects.

Cancer patients treated with immune checkpoint inhibitors may develop alopecia, but some hair regrowth is possible with treatment.

The article concludes that better understanding gene regulation related to seasonal changes can offer insights into the mechanisms of seasonal timing in mammals.

The study found that diseases can be grouped by symptoms and that the accuracy of predicting disease-related genes varies with the data source.

Skin grafting can help repigment vitiligo, but it's less effective for widespread cases due to the Koebner phenomenon.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

SHISA6 helps maintain certain stem cells in mouse testes by blocking signals that would otherwise cause them to differentiate.

Human skin cells produce proenkephalin, which changes with environmental factors and skin diseases.