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Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Finasteride caused long-term sexual and non-sexual side effects in young men with hair loss.

A woman had both Graham Little-Piccardi-Lassueur syndrome, causing hair loss, and complete androgen insensitivity syndrome, making her genetically male but physically female. This suggests androgens don't affect the hair loss condition.

In Japan, sex reassignment surgery for gender identity disorder faces challenges and needs better medical support and education.

Estrogen is important for keeping adult mouse nipple skin healthy by controlling certain cell signals.

SOX2 is crucial for skin cell function and hair growth, and it plays a role in skin cancer and wound healing.

Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.

Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

A woman with breast cancer developed a rare condition causing excessive fine hair growth on her face and body.

BMP6 and Wnt10b control whether hair follicles are resting or growing.

Most skin changes during pregnancy go away after giving birth.

PTHrP and its receptor can control blood vessel growth and hair development in mouse skin.

An 81-year-old woman's severe male hormone symptoms were caused by an ovarian tumor, which was treated with surgery.

The study found stem cells in minor salivary glands that can differentiate and are involved in tumor formation when exposed to tobacco.

Adult stem cells with Tp63 can form hair and skin cells when placed in new skin, showing they have hidden abilities for skin repair.

Psychotropic drugs can cause hair loss or excessive hair growth.

Dermal papilla cells are key for hair growth and color, influencing hair type and size, and their interaction with stem cells could help treat hair loss and color disorders.

The drug BAY 1158061 is safe, well-tolerated, and shows potential for treating diseases related to prolactin.

The dog's skin condition improved after removing a tumor that was causing hormone imbalances.

Newly born mesenchymal cells quickly spread out in response to tissue tension during early development.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

The document concludes that non-endocrine alopecia in pets varies in treatment effectiveness and often has a poor prognosis, especially in cats.

Spironolactone can cause side effects like high potassium levels and breast enlargement, and patients need careful monitoring.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Understanding where cancer cells come from helps create better prevention and treatment methods.

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.