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Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Hidradenitis suppurativa, a chronic skin disease, can be managed with antibiotics, lifestyle changes, and in severe cases, surgery. Early diagnosis and careful planning are key, and laser treatment can be an efficient solution for mild to severe cases.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Understanding where cancer cells come from helps create better prevention and treatment methods.

Diet changes can protect against harmful environmental effects on fetal development.

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

The ZIP7 gene helps control zinc levels in cells by moving zinc from the Golgi apparatus to the cytoplasm.

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

Hair loss needs more research for better treatments.

Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.

Androgens can cause hair growth in some areas and hair loss on the scalp.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Estrogen therapy can reduce skin aging but has cancer risks.

Stem cell self-renewal is complex and needs more research for full understanding.