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The Cochrane Database published its 5000th review in 2012, covering various health topics and updating conclusions based on new research.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Early detection and intensive treatment of diseases caused by Staphylococcus aureus toxins are crucial for reducing severe health effects.

Some drugs can cause skin, nail, and hair problems, which are important for healthcare professionals to recognize and report.

Voriconazole can cause serious side effects, especially in long-term use.

Minoxidil effectively treats severe hypertension but may cause side effects, so careful monitoring is needed.

The document concludes that rapid identification, isolation, and strict infection control are crucial to manage SARS outbreaks.

Despite progress, better treatments and understanding are needed for the high rates of long-term issues and deaths linked to eating disorders.

Some heart drugs show promise for other conditions, but more research is needed to confirm their effectiveness and safety.

Both ruxolitinib and tofacitinib are effective and safe for treating severe alopecia areata, but relapses are common.

Cyclosporin is effective for treating skin conditions in small animals, but requires careful dosing and monitoring for side effects.

Chemotherapy often causes hair loss, nail changes, and mouth issues, but these are usually manageable.

Accurate diagnosis and treatment are crucial for managing superficial fungal infections, with terbinafine being the best oral treatment for nail infections.

Some medications can cause hair loss, but stopping the drug usually leads to recovery within 3 months.

Some patients developed skin inflammation after obesity surgery, and a medication called dapsone helped treat it.

Toxic epidermal necrolysis is a severe skin reaction often linked to drugs, requiring careful medication use and supportive care.

Germ-free rats need biotin for growth and have different vitamin metabolism compared to regular rats.

Azathioprine's effectiveness and safety require careful monitoring and more research, especially regarding its use with corticosteroids and the role of TPMT status in patients.

The study found that combining different databases gives a better estimate of drug side effects in hospitals.

Stronger corticosteroids cause more skin damage in hairless dogs, similar to effects in humans.

Severe COVID-19 may cause hair loss, and doctors recommend supplements and topical treatments to manage it.

Minoxidil effectively treats female pattern hair loss.

Scalp cooling is the most effective FDA-approved method to prevent chemotherapy-induced hair loss, but more research is needed for other treatments.

APS-1 in Italy shows diverse AIRE mutations and various autoimmune issues.

ICL is a condition with low CD4+ T cells like AIDS but not caused by HIV, and normal CD4+ T cell counts may vary between men and women.

Toxic Epidermal Necrolysis is a rare, serious skin condition that can affect anyone, is more common in women, and may be linked to genetics, with a 20% mortality rate mainly due to sepsis.

A boy with chromosome 13q deletion syndrome developed eye cancer, a woman with breast cancer lost vision due to a rare side-effect of her treatment, a man's vision worsened after using a hair loss drug, and two rare disorders were discussed. Optical Coherence Tomography is useful for diagnosing and monitoring these conditions.

Dogs with generalized discoid lupus erythematosus have similar symptoms to humans and need continuous treatment.

Eye exams are crucial for kids with 13q deletion syndrome, tamoxifen can cause vision loss, Propecia may lead to cataracts, Lipoid Proteinosis causes skin bumps, and OCT is useful for diagnosing macular diseases.

Severe digestive issues in DRESS need early endoscopy for better treatment.