research Biofabrication of Human Skin with Its Appendages
Current methods can't fully recreate skin and its features, and more research is needed for clinical use.
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research Whole Genome Sequencing Analysis of Alpaca Suggests TRPV3 as a Candidate Gene for the Suri Phenotype
The TRPV3 gene variant may cause the long-haired suri alpaca coat.
research Development of Pigmented Reconstructed Human Epidermis Model Containing Human Melanoblasts from Keratinocyte Culture
The created skin model with melanoblasts improves the study of skin color and offers an alternative to animal testing.
research Behavior of the Two Circulating Androgens Testosterone and DHEA and Their Main Intracellular Metabolites in an Androgen-Sensitive Sebocyte Cell Line
Testosterone affects androgen receptors and lipid storage in cells, while DHEA does not convert to testosterone or affect these receptors in the same way.
research Decay of Skin-Specific Gene Modules in Pangolins
Pangolins have lost some skin-related genes, but kept others, leading to their unique scales and skin features.
research The Hirsute Woman: Challenges in Evaluation and Management
Most hirsutism cases are due to PCOS, and treatment focuses on lowering testosterone and blocking its effects.
research Extracellular Fraction of Adipose Tissue as an Innovative Regenerative Approach for Vitiligo Treatment
Fat tissue extract may help treat vitiligo by reducing cell stress and promoting skin repair.
research Medicinal Plants for Skin Health: A Holistic Review of Botanical Interventions
Certain plants like Aloe vera and Neem are effective and safe for treating various skin conditions.
research Molecular Pathology of Skin Adnexal Tumors
New markers and pathways have been found in skin tumors, helping better understand and diagnose them.
research Convergent Decay of Skin-Specific Gene Modules in Pangolins
Pangolins have lost some skin-related genes, but kept others, showing complex skin evolution.
research MicroRNAs in the Skin: Role in Development, Homeostasis, and Regeneration
MicroRNAs are important for skin health and could be targets for new skin disorder treatments.
research Functional Skin Grafts: Where Biomaterials Meet Stem Cells
Advancements in creating skin grafts with biomaterials and stem cells are promising, but more research is needed for clinical application.
research Basal Cell Carcinoma, Hedgehog Signaling, and Targeted Therapeutics: The Long and Winding Road
New treatments targeting the Hedgehog pathway can help treat advanced skin cancer but may have side effects and their effectiveness in early stages is unknown.
research From Stem Cells Protection to Skin Microbiota Balance: Orobanche Rapum Extract, a New Natural Strategy
Orobanche rapum extract rejuvenates skin and protects skin bacteria, leading to healthier skin.
research Differential Activity of 2-Methylene-19-Nor Vitamin D Analogs on Growth Factor Gene Expression in Rhino Mouse Skin and Comparison to All-Trans Retinoic Acid
Some vitamin D analogs can thicken skin and reduce pore size like a common acne treatment, with one analog also affecting skin growth factors.
research Isolating Subpopulations of Human Epidermal Basal Cells Based on Polyclonal Serum Against Trypsin-Resistant CSPG4 Epitopes
The research found a way to identify and study skin cells with stem cell traits, revealing they behave differently in culture and questioning current stemness assessment methods.
research Novel Advances of Histone Modification in Inflammatory Skin Diseases and Related Treatment Methods
Histone modification is key in treating chronic inflammatory skin diseases.
research Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs
More personalized and effective treatments for androgenetic alopecia are needed.
research C/EBPα and C/EBPβ Are Required for Sebocyte Differentiation and Stratified Squamous Differentiation in Adult Mouse Skin
C/EBPalpha and C/EBPbeta are crucial for normal skin and oil gland cell development in adult mice.
research A Novel Epithelial Keratin, hK6irs1, Is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells of the Human Hair Follicle
A new keratin, hK6irs1, is found in all layers of the hair follicle's inner root sheath.
research Abnormal Inner Root Sheath of the Hair Follicle in the Loose Anagen Hair Syndrome: An Ultrastructural Study
Loose anagen hair syndrome is caused by structural abnormalities in the hair follicle's inner root sheath.
research Human Hair Follicle Stem/Progenitor Cells Express Hypoxia Markers
Human hair follicle stem cells show signs of low oxygen levels, which may be important for hair growth and preventing baldness.
research MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells
miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.
research Hair Follicle Stem Cells: The Signaling Hub of the Skin
Hair follicle stem cells are important for maintaining healthy skin and interact with many signals.
research Sequential Cyclic Changes of Hair Roots Revealed by Dermoscopy Demonstrate a Progressive Mechanism of Diffuse Alopecia Areata Over Time
Dermoscopy shows that diffuse alopecia areata progresses through specific hair growth stages.
research VEGF Upregulates VEGF Receptor-2 on Human Outer Root Sheath Cells and Stimulates Proliferation Through ERK Pathway
VEGF stimulates hair cell growth and increases growth receptor levels through a specific signaling pathway.
research Keratin 71 Mutations: From Water Dogs to Woolly Hair
A mutation in the KRT71 gene causes a hair disorder by disrupting hair follicle structure and texture.
research Open Questions in Hidradenitis Suppurativa Research: A Hair Biologist's Perspective
The conclusion suggests that early signs of hidradenitis suppurativa may start in the hair follicle, with genetic and immune factors playing a role, highlighting the need for more research on the hair follicle's immune system.
research Rare Diagnosis of a Proliferating Pilar Tumor in a Facial Hairline Cyst
The lump on a woman's scalp was a rare, potentially cancerous tumor from the hair follicle, not a common cyst.
research Clinical, Histopathologic, Immunohistochemical, and Electron Microscopic Findings in Cutaneous Monkeypox: A Multicenter Retrospective Case Series in Spain
Monkeypox skin lesions show full-thickness skin death and swollen skin cells, with the virus found in affected cells.