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The document suggests creating a validated score to diagnose Cushing's Syndrome and considers plasma steroid profiling as a simpler diagnostic method.

The document concludes that PCOS has a strong genetic component, but more research is needed to fully understand the specific genes involved.

Vertical sleeve gastrectomy improved metabolism, behavior, and reproduction in obese rats with PCOS.

The method can measure multiple steroids in human hair to study long-term steroid metabolism, especially in newborns and children.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Simvastatin may help manage symptoms in women with non-classic congenital adrenal hyperplasia by lowering cholesterol and certain hormone levels.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

Aleglitazar and its major metabolite are safe enough to proceed to Phase 3 clinical trials.

Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Gastric exclusion surgery caused major weight loss and health improvements but led to some anemia and vitamin deficiencies.

Using anabolic androgenic steroids can cause serious, lasting health problems in many parts of the body.

Male rats have androgen receptors in their liver, which are different from proteins that bind estrogen.

Men with liver cancer have higher levels of a specific testosterone byproduct in their liver and blood, despite overall lower male hormone levels.

The treatment reduced hair growth and testosterone in women with excess hair and had some effects on stress responses.

Topical tretinoin may increase beard hair density.

Zinc helps reduce the severity of depression.

Spironolactone, a heart and liver drug, has new uses including cancer treatment, viral infection prevention, and skin condition improvement.

Cytokines and neuropeptides are key in controlling androgen levels, affecting skin and hair conditions.

Ketoconazole can treat ovarian hyperandrogenism but should be used cautiously with monitoring and birth control.

Neurosteroids play a key role in controlling the brain-adrenal gland activity in pregnant sheep, both in normal and stressful situations.

Hormone levels in hair vary across the head, with the highest concentration of a key hormone linked to hair loss at the top.

Women with Polycystic Ovary Syndrome have a higher chance of getting depressed.

Nutrafol might help reduce hair loss due to inflammation, but more evidence is needed.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Shift work disrupts the body's natural clock, leading to health problems.

Androgen use may increase the risk of stroke, but more research is needed.

Misbehaving hair follicle stem cells can cause hair loss and offer new treatment options.