research Crystal Structure of Steroid Reductase SRD5A Reveals Conserved Steroid Reduction Mechanism
The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.
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research Factors Driving Unique Urination Phenotypes of Male and Female 9-Week-Old C57BL/6J Mice
Testosterone significantly affects urination differences between male and female mice.
research Deletion of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in FoxD1-Lineage Mesenchymal Cells Leads to Congenital Truncal Alopecia
Removing a specific gene in certain skin cells causes hair loss on the body by disrupting normal hair development.
research Witnessed Trauma Exposure Induces Fear in Mice Through a Reduction in Endogenous Neurosteroid Synthesis
Seeing trauma causes fear in mice by lowering their natural fear-reducing hormones.
research MicroRNA-205 Promotes Hair Regeneration by Modulating Mechanical Properties of Hair Follicle Stem Cells
MicroRNA-205 helps hair grow by changing the stiffness and contraction of hair follicle cells.
research Biocompatibility Of Kaps-Depleted Residual Hair
KAP-depleted hair causes less immune response and is more biocompatible for implants.
research Primary Cilia Regulate Meibomian Glands Development and Dimensions Without Impairing Lipid Composition of the Meibum
Primary cilia affect the size and oil production of eye glands but not the oil's makeup.
research Disrupted Cholesterol Biosynthesis and Hair Follicle Stem Cell Impairment in the Onset of Alopecia
Disrupted cholesterol production impairs hair follicle stem cells, leading to hair loss.
research Spatiotemporal Dynamics of Sensory Neuron and Merkel-Cell Remodeling During Epidermal Homeostasis
Merkel cells stabilize nerve endings in the skin, and they change independently of each other.
research Targeting PrfA From Listeria Monocytogenes: A Computational Drug Repurposing Approach
The research suggests Dutasteride and Solifenacin may be effective against the bacterium causing listeriosis.
research Impact of Anti-Androgen Therapies on COVID-19 Susceptibility: A Case-Control Study in Male Population from Two COVID-19 Regional Centers of Lombardy, Italy
Men taking 5-alpha reductase inhibitors for prostate issues may be less likely to experience severe COVID-19, but it doesn't prevent ICU admission or death.
research A Human Prenatal Skin Cell Atlas Reveals Immune Cell Regulation of Skin Morphogenesis
Immune cells are essential for early hair and skin development and healing.
research Scarring Hair Follicle Destruction Is Driven by the Collapse of EGFR-Protected JAK-STAT1-Sensitive Stem Cell Immune Privilege
A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.
research Stabilization of Beta-Catenin Promotes Melanocyte Specification at the Expense of the Schwann Cell Lineage
Activating β-catenin increases melanocytes and decreases Schwann cells.
research Diverse Northern Asian and Jomon-Related Genetic Structure Discovered Among Socially Complex Three Kingdoms Period Gaya Region Koreans
The DNA of ancient Koreans from the Three Kingdoms period shows a mix of northern Chinese and Japanese-Jomon ancestry, revealing two distinct genetic groups.
research Intraoperative Bioprinting of Human Adipose-Derived Stem Cells and Extracellular Matrix Induces Hair Follicle-Like Downgrowths and Adipose Tissue Formation During Full-Thickness Craniomaxillofacial Skin Reconstruction
Printing human stem cells and a special matrix during surgery can help grow new skin and hair-like structures in rats.
research Neutrophil Extracellular Traps Impair Regeneration
Neutrophil extracellular traps slow down hair follicle healing after injury.
research Distinct Tooth Regeneration Systems Deploy a Conserved Battery of Genes
Different fish use the same genes to regrow teeth.
research Allosteric Interactions Prime Androgen Receptor Dimerization And Activation
Certain interactions help prepare the androgen receptor for pairing and activation, which is important for its role in development and disease.
research Blood Group O and Post-COVID-19 Syndrome
People with blood group O may have a higher risk of developing post-COVID-19 syndrome.
research Developing Patient-Reported Outcome Measure for Hair and Skin Disorders
The goal is to create a tool for patients to report their experiences with various hair and scalp disorders.
research A Systematic Review and Meta-Analysis of Polycystic Ovary Syndrome and Mental Health Among Black Asian Minority Ethnic Populations
Polycystic Ovary Syndrome (PCOS) increases the risk of mental health disorders, but its impact on Black Asian Minority Ethnic groups isn't fully known.
research Cell Surface Receptor Kinase FERONIA Linked to Nutrient Sensor TORC Signaling Controls Root Hair Growth at Low Temperature Linked to Low Nitrate in Arabidopsis Thaliana
A protein called FERONIA helps control root hair growth in response to cold and low nitrogen by activating nutrient-sensing pathways in a plant called Arabidopsis.
research Protein Kinase C Is a Key Target for Attenuation of Leigh Syndrome by Rapamycin
Rapamycin may help treat Leigh syndrome by targeting protein kinase C.
research A Direct Link Between Prss53, Hair Curvature, and Skeletal Dysplasia
The gene Prss53 affects hair shape and bone development in rabbits.
research Early Skin Seeding Regulatory T Cells Modulate PPARγ-Dependent Skin Pigmentation
Early regulatory T cells are crucial for normal skin pigmentation.
research De Novo Assembly and Annotation of Asiatic Lion (Panthera Leo Persica) Genome
The Asiatic lion has very low genetic diversity and unique genetic traits, highlighting the need for its conservation.
research Finding Long-COVID: Temporal Topic Modeling of Electronic Health Records from the N3C and RECOVER Programs
Long-COVID has diverse, long-term health impacts, especially in young people.
research Complementary Evolution of Coding and Noncoding Sequence Underlies Mammalian Hairlessness
Hairless mammals have genetic changes in both their protein-coding and regulatory sequences related to hair.
research Multidimensional Assessment of Adverse Events of Finasteride: A Real-World Pharmacovigilance Analysis Based on FDA Adverse Event Reporting System (FAERS) from 2004 to April 2024
Finasteride has various adverse effects, including sexual dysfunction and mental health issues, which vary by age and gender.