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The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).

CCT128930 is a promising new drug that effectively targets and inhibits a cancer-related protein, showing potential for cancer treatment.

Male yak hair growth is influenced by DHT synthesis, which is promoted by 5α-red1 and AR during growth phases, while E2 may inhibit growth through ERα.

Some treatments for autoimmune hair loss work, but JAK inhibitors like tofacitinib are promising for regrowth.

5α-reductase inhibitors like finasteride and dutasteride can help treat skin disorders stimulated by androgens, such as hair loss and acne.

Best treatment for Frontal Fibrosing Alopecia is 5-alpha-reductase inhibitors and intralesional corticosteroids.

MJ04, a new compound, effectively promotes hair growth and is a potential topical treatment for hair loss.

Certain substances can protect against ear damage from some antibiotics in zebrafish.

Understanding and managing side effects of hedgehog pathway inhibitors can improve treatment for advanced basal cell carcinoma.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

Some treatments like intralesional steroids and 5α-reductase inhibitors are effective for frontal fibrosing alopecia, but more research is needed.

Personalized treatment with inhibitors, minoxidil, and laser therapy helps hair loss.

Applying certain inhibitors to the skin can promote hair growth without harming cells.

Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.

Reduced androgens linked to kinky hair disorder and hair loss; 5a-reductase inhibitors may help.

Taking 5 alpha reductase inhibitor medication slightly increases the risk of depression, especially as you get older.

Birth control pills change the activity of certain inflammation and blood clotting genes in women with PCOS.

A specific pathway involving AR, miR-221, and IGF-1 plays a key role in causing common hair loss.

Tamsulosin increases the risk of floppy iris during eye surgery.

Finasteride and dutasteride are effective in treating male hair loss but can cause sexual side effects and birth defects.

5-alpha reductase inhibitors, like finasteride and dutasteride, are used for prostate issues, hair loss, and excessive hair growth, may help with COVID-19, but can cause sexual and mental health side effects, and their use in preventing prostate cancer needs more examination.

5α-Reductase inhibitors may increase depression risk but not dementia or suicide.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Dihydrotestosterone treatment on 2D and 3D-cultured skin cells slows down hair growth by affecting certain genes and could be a potential target for hair loss treatment.

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.

Dutasteride and finasteride can help increase hair growth gene expression but need further improvement.

Substances from fat-derived stem cells can promote hair growth and counteract hormone-related hair loss by activating a key hair growth pathway.