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Ovarian steroid cell tumors should be considered in adults with hirsutism and high testosterone, with surgery as the main treatment.

Lower testosterone levels in men may be linked to a higher risk of severe coronary artery disease.

The document concludes that personalized treatment, including lifestyle changes and medication, is essential for managing PCOS in teenagers, while also addressing their psychological well-being.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

New treatments for male hypogonadism are effective and should be personalized.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

People with PCNT mutations often develop severe insulin resistance and early-onset diabetes during childhood or adolescence.

Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

High levels of TNF-α may contribute to obesity and insulin resistance in PCOS, but not due to the C850T genetic variation.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

Lower lipin 1β in belly fat is linked to insulin resistance in people with polycystic ovary syndrome.

A combined drug and laser treatment improved hirsutism in a PCOS patient, also enhancing her heart health and requiring regular liver and kidney checks.

The document concludes that Rabson-Mendenhall syndrome requires novel treatments for insulin resistance and emphasizes the importance of dental care in affected patients.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

Some skin diseases and their treatments can negatively affect male fertility.

Finasteride can cause lasting sexual dysfunction, depression, and other side effects, needing more research for treatment.

Testosterone is crucial for development, growth, and various body functions in mammals.

The conclusion is that certain genetic factors and blood types may affect COVID-19 severity, but changes in ACE2 and TMPRSS2 genes are not clearly linked to it.

The document concludes that skin and nail changes can indicate various underlying health conditions.

Gut flora changes could potentially indicate depression, but more research is needed.

Sebum production varies by individual and is influenced by age, gender, and hormones, affecting skin and hair health.