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People with Down syndrome have a higher risk of skin disorders and need better screening and treatment.

Suppressing very long chain fatty acids is linked to skin cancer.

Tofacitinib is a potential alternative treatment for alopecia totalis, especially in patients with a shorter duration of the condition and more preserved hair follicles, but the overall response rate is low.

Acne is not a key diagnostic feature for PCOS, postadolescent men with acne may have insulin resistance, melanoma patients often have few moles, tumor size in CSCC indicates higher risk of serious outcomes, and hidradenitis suppurativa is linked to higher risk of heart problems and death.

Some plant extracts may treat livestock diseases, certain animal treatments are safe and effective, but more research on drug safety and resistance is needed.

Undergraduate research experiences boost students' research skills, confidence, and career aspirations.

Metformin is safe in early pregnancy for women with PCOS and may reduce certain risks.

The document concludes that various medications and treatments can have significant, sometimes adverse, effects on health outcomes.

The issue included new and updated reviews on various health interventions, with significant findings on weight loss, psychological therapies, cancer treatment, and more.

PSA screening's effectiveness in reducing prostate cancer deaths can vary based on trial design and participant compliance.

Patients with metabolic syndrome had lower Gleason scores when diagnosed with prostate cancer.

Antibiotic ointment and petrolatum ointment heal wounds similarly; iron deficiency isn't linked to certain hair loss in women; griseofulvin and terbinafine are equally effective for fungal scalp infections but work better on different types.

Lifestyle changes like diet and exercise are key for treating overweight women with polycystic ovary syndrome.

The document concludes that early diagnosis and treatment of PCOS in teenagers is important for managing symptoms and preventing long-term health problems.

Biologic agents can be effective for rheumatic diseases but have risks like infections and require careful monitoring and patient information.

Check serum ferritin levels and total blood count for women with diffuse hair loss.

Microneedling with topical dutasteride improves hair growth in men with hair loss and is safe to use.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.

Women with PCOS have a higher risk of diabetes and heart problems, especially when they get older.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

COVID-19 can cause skin issues like rashes and "COVID toes," and people with skin conditions should adjust their treatments if they get the virus.

Doxil showed some effectiveness against advanced prostate cancer but caused severe side effects at higher doses.

A new gene, JMJD1C, may affect testosterone levels in men.

Baricitinib is effective and safe for treating severe alopecia areata.

Mitoxantrone with a corticosteroid helps manage symptoms for some advanced prostate cancer patients but doesn't extend life.

High doses of cyproterone acetate increase the risk of brain tumors in women, but the risk decreases after stopping the medication.

Ginseng may help treat cancer and reduce treatment side effects, but more research is needed.

Obese women with PCOS are more likely to have fatty liver disease.