The genetic basis of dermatophytosis skin infection susceptibility

This study investigates the genetic basis of susceptibility to dermatophytosis, a fungal infection affecting skin, nails, and hair, impacting 20% of the global population. A genome-wide association meta-analysis involving over 250,000 cases and 1,370,000 controls identified 30 significant genetic loci linked to the condition. Key associations were found with genes related to keratin lifecycle, skin integrity, immune defense, and obesity, such as ZNF646, HLA-DQB1, FLG, FTO, SLURP2, and KRT77. These findings suggest that genetic factors influencing skin health and body mass index may contribute to dermatophytosis risk, offering potential targets for managing the infection.