The Effect of the Drug Minoxidil on Hair Growth

The document discussed the effects of minoxidil on hair growth, initially observed during its use for treating hypertension. It was found that topical application of minoxidil on the scalp was effective in promoting hair growth, particularly in individuals with less severe hair loss. The mechanism was thought to involve vasodilation, but direct effects on keratinocytes were also noted, such as slowing cell senescence and prolonging the anagen phase of hair growth. Minoxidil was also found to suppress lymphocyte activity and inhibit lysyl hydroxylase activity, while blocking PGI2 synthesis. No cytoplasmic binding protein for minoxidil was identified.