Retardation of Hair Follicle Development by the Deletion of TrkC, High-Affinity Neurotrophin-3 Receptor

    September 1999 in “ Journal of Investigative Dermatology ”
    Natalia V. Botchkareva, Vladimir A. Botchkarev, Martin Metz, Inmaculada Silos‐Santiago, Ralf Paus
    TLDR Lack of TrkC receptor delays hair follicle development.
    The study explored the impact of the TrkC receptor on hair follicle development by using TrkC knockout mice. It found that the absence of TrkC significantly delayed hair follicle morphogenesis, as indicated by earlier development stages and reduced skin thickness compared to wild-type mice. This suggested that neurotrophin-3 (NT-3) promoted hair follicle development through TrkC signaling, possibly involving Wnt and BMP pathways. The study had a small sample size, with 3 TrkC knockout and 3 wild-type mice, underscoring the role of NT-3/TrkC in hair follicle development.
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