Primary Amenorrhoea

April 2024 in “ International Journal of Advanced Multidisciplinary Research and Studies ”

Adan Khan, Kinza Younas, Euan Kevelighan

primary amenorrhea hormonal disturbances HPO axis hyperandrogenemia chromosomal abnormalities thelarche

Primary amenorrhea is the failure to commence menstruation and can be due to hormonal disturbances or anatomical problems. A normal uterovaginal anatomy and functional HPO axis are essential for menstruation. Investigations should be conducted at age 13 if there are no secondary sexual characteristics, and at age 15 if there are. Early referral is advised if there is suspicion of chromosomal abnormalities, hyperandrogenemia, anatomical issues, or if amenorrhea persists for 5 years after thelarche. A multidisciplinary team approach is crucial to support patients and families with evidence-based knowledge for decision-making, addressing their individual needs for the best outcome.

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Primary Amenorrhoea

Research cited in this study

research Where Have the Periods Gone? The Evaluation and Management of Functional Hypothalamic Amenorrhea

research Non-Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Revisited: An Update with a Special Focus on Adolescent and Adult Women

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research Reproductive Dysfunction in Women with Epilepsy

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

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