Neurotrichosis: Hair‐shaft Abnormalities associated with Neurological Diseases

The document discussed six children with both hair-shaft abnormalities and neurological diseases, including Pollitt syndrome, biotin deficiency, Menkes disease, and argininosuccinic aciduria. It was noted that the child with biotin deficiency experienced normal hair growth after receiving oral biotin therapy. Hair-shaft abnormalities, such as trichorrhexis nodosa, monilethrix, and pili torti, were best visualized using scanning electron microscopy (SEM) rather than light microscopy (LM). These abnormalities were not specific or pathognomonic but indicated a group of neurological disorders, including treatable inborn errors of metabolism. The term "neurotrichosis" was proposed to classify these disorders.