Exploring the therapeutic potential of different sources of mesenchymal stem cells: a novel approach to combat burn wound infections

Burn injuries pose significant global health challenges due to their potential to cause severe inflammatory responses, organ dysfunction, and infections that can lead to sepsis. Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic approach for enhancing burn wound healing. Since 2000, MSCs have been increasingly used in regenerative medicine due to their ability to promote angiogenesis, exhibit anti-inflammatory effects, and regenerate damaged tissue. These cells can be sourced from bone marrow, fat, umbilical cord, and amniotic membrane. The review highlights the need to address preclinical and clinical challenges to optimize MSC therapy, thereby advancing its application in treating burn wounds and reducing scarring and associated functional and cosmetic issues.