Chitosan Nanoparticulate System Loaded with Cannabidiol: A Topical Formulation for Potential Alopecia Management

This study explores a novel topical formulation for alopecia treatment by encapsulating cannabidiol (CBD) in chitosan nanoparticles, which enhances CBD solubility and allows targeted delivery to hair follicles. The formulation uses chitosan/β-glycerophosphate (CS/β-GP) nanoparticles with glycerol as an emulsifier, achieving a nanoparticle size of 259.04 nm suitable for hair follicle penetration. The system's pH of 5.5 aligns with scalp physiology, minimizing irritation. The study highlights the potential of this formulation as a scalable platform for transdermal delivery of hydrophobic compounds, offering a promising approach for managing alopecia with potentially more effective and safer outcomes compared to conventional treatments.