All-Trans Retinoic Acid Induced Differentiation of Amelanotic Melanocytes in Human Hair Follicle
January 2004
in “
Linchuang pifuke zazhi
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TLDR All-trans retinoic acid helps amelanotic melanocytes in hair follicles develop and produce pigment while reducing their growth.
The study investigated the effects of all-trans retinoic acid on amelanotic melanocytes (AMMC) from human hair follicles. It was found that all-trans retinoic acid increased the expression of tyrosinase (TYR) and tyrosinase-related protein (TRP)-1, but not TRP-2, and promoted dendrite formation in some AMMC. Additionally, it inhibited the proliferation of these cells, potentially through apoptosis, as all-trans retinoic acid is known to induce apoptosis in tumor cells. The findings suggested that all-trans retinoic acid could promote differentiation and melanogenesis in AMMC while inhibiting their proliferation.
