ACELL
Dec 2008
Tressless News
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Joseph Greco has been sending out some scans from a hair transplant industry magazine regarding Platelet Rich Plasma as used in hair transplant surgeries.
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Acell, a Jessup, Maryland-based company, has begun providing hair transplant doctors with its skin-regenerating powder. This may possibly provide an unlimited source of donor hair.
Dr. Robert Jones now has access to Acell’s Extracellular Matrix (ECM) products for wound healing. Anyone interested in signing up as a test patient, please email hairsite@aol.com immediately for details.
From Hairsite
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This post is outdated. For new information, see: Intercytex and regenerative hair therapy: what are they waiting for?
He only looks sad still; he died while waiting for hair
Intercytex, the UK-based biotechnology company and hair multiplication darlings of the moment, have released the final results from their Phase II trials for their flagship hair product, ICX-TRC.
The [...]
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A family of Florida-based hair transplant doctors want to extract your blood and inject it back into your scalp. More specifically, your Platelet Rich Plasma.
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Video from MSNBC showing Follica’s co-founder, George Cotsarelis, predicting a market release “within a few years” under “perfect” circumstances. It is also confirmed that human trials should begin “within the next year or two”.
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Body hair transplant
17,065 units
Aug 2008
News From Elsewhere
- Balding Blog - Making Sense of Hair Loss Drug StatsDr. Rassman, you have said before that minoxidil works for about half of men. The box says that minoxidil has only been proven to work for men experiencing hair loss at the apex/top of head and not for men that are balding from the front. Are these clinical studies made up of men that are [...]
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- Balding Blog - Donor Scarring from Hair Plugs Done About 30 Years AgoThirty years ago I had 4 or 5 sessions hair transplant sessions done using the old punch graph method. For most of those years I was fairly satisfied. Lately that has not been the case. The appearance of corn rows is starting to show in the front and it is getting harder to [...]
- Balding Blog - Does a Hairline Shift When Closing a Strip Procedure?Hi, doc. I’ve been researching hair-transplantation, and I have a question concerning F.U.T. (strip-harvesting): I understand, in this method, a strip is excised from the back of the scalp, the wound then closed. I wonder, then, is not the overall surface of the scalp reduced in this procedure? After two or three procedures, especially, (or [...]
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- Balding Blog - I Just Moved and Now Iâm Losing HairI recently moved to US (bay area) and have been noticing a lot of hair fall. Slightly pulling my hair causes them to come out. I have no serious illness etc. What could be causing the increased hair loss? Thanks! It could be a variety of things. Perhaps it is your genetics and the timing was coincidental [...]
- Balding Blog - Settling In to a Hair Loss Pattern?Hi, Dr. Rassman. Thanks for answering all of our questions. My question is, How likely is it for someone to “settle in” to a level of hair loss (Norwood 3A, for example) and not see any more rapid loss for a period of time (years, for example)? Do some people get to a certain level of [...]
- Balding Blog - Press Release - New Laser Cleared by FDA for Female Hair LossSnippet from the press release: The United States Food and Drug Administration (FDA) has just cleared a new laser proven to regrow hair in women. The FDA ruling was based on a study performed by Dr. Grant Koher which showed that low level laser light, specifically with a precise wavelength, provides a medically significant treatment for [...]
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- Blogspot.com - Soy Isoflavones and Chili Pepper for Hair Growth â Experiment BeginsThe hotter the pepper, the more capsaicin it contains. (Photo by Andreas Adermark)I've written so many posts on soy isoflavones and hair growth that I figured it's time to start another experiment to see for myself whether the claims are true.Even though it looks like soy isoflavones alone are sufficient to increase dermal levels of IGF-1 and thus promote hair growth, the most effective combination seems to be isoflavones and capsaicin. If you haven't seen the pictures from that paper for some reason, I recommend taking a look at the latter link. This combination is the one I will be testing.The soy isoflavones supplement I have is by NOW Foods. It contains 60 mg of isoflavones (genistein, daidzein and glycitein) per capsule. This is slightly less than the 75 mg used in the human study, but since I don't want to take 120 mg per day, it'll have to do.As for capsaicin, I'm going with the natural route and adding chili pepper to my foods during the experiment. There are capsaicin supplements too, but since I like spicy foods anyway, I don't think supplements are worth the extra money in this case.The only problem is that it's pretty difficult to estimate the amount of capsaicin; a tablespoon of ground chili will contain anywhere between 0.8 mg and 480 mg of capsaicin. In the study, 7 mg per day was consumed, so if I manage to eat a tablespoon, I should have decent odds of ingesting at least as much capsaicin. As you can see, this is not an exact replica of the human study, but I think my own experiment will be very close to what other people might try at home. The study lasted for 5 months, which is how long you should give any treatment before realistically expecting results. I will post an update after I run out of capsules and we'll see what happens then.Keep in mind that this is not the only thing I have going on at the moment that might affect hair growth. Though not technically experiments, I've been using ketoconazole and piroctone olamine shampoos regularly, because the science behind them looks pretty good. I'm also consuming some ground flax seeds every now and then, which could be beneficial for hair.Since I started to use these three things, I've noticed a slight decrease in the number of hairs lost daily. Whereas I counted 60-80 before, I now seem to lose about 40-50 hairs daily. Both of these figures are within the normal range, so these additions to my health regiment are mostly about preventing (or at least delaying) any future hair loss. Still, if the hair growth promoting effect of isoflavones and capsaicin is as strong as the rodent and human studies show, I would expect some visible changes even in people without androgenic alopecia.Lastly, my experiments with retinoids and an Ayurvedic topical called Nutrich oil are still running. I'm applying both of them on my temples, one on the left and the other on the right, to see if they increase hair growth. So far I have not noticed any dramatic changes, so I don't think they will obfuscate the results of this experiment too much.I'll keep you updated on how things go. Meanwhile, if you've tried soy isoflavones or capsaicin, drop a comment and share your experiences!For more information on hair growth, see these posts:BioSil, JarroSil & Beer â Silicon Experiment ConclusionEmu Oil vs. Hair Again® Topical Gel: Hair Growth Battle ConclusionEclipta Alba Extract Grows Hair Quicker than MinoxidilDo Flax Lignans Reduce Hair Loss from MPB?
- Delicious.com - Hair Loss TreatmentSvenson is a leading whole at the vanguard in research and development of solutions for hair and scalp problems using the most advanced technologies. With over fifty years of trichological expertise and information, Svenson offers scientific diagnosis and customized & effective solutions to virtually all hair problems. Operating a global network of hair centers these days, there are fifty four branches across Asia region, together with China, Hong Kong, Singapore, Taiwan, Korea, Indonesia, Brunei, Thailand, and of course, Malaysia.
- Blogspot.com - Soy Isoflavones Grow Hair by Increasing IGF-1 in the SkinFood sources of isoflavones include tofu and miso soup. (Photo by sokole oko)Many of you have probably heard that soy isoflavones may be good for hair loss. How exactly dietary isoflavones work to promote hair growth is less clear, however.As long-time readers may remember, I've written before about the effects of dietary isoflavones on humans and animals. For example, in male rats even a relatively low amount of soy isoflavones reduces DHT and increases testosterone. This alone would probably be enough to explain hair growth in rodents.Of course, humans are a more difficult case. Most of the things that show promise in mice or rats don't work for humans with androgenic alopecia in the end. The good news is that soy isoflavones reduce DHT even in humans. The bad news is that the reduction may not be great enough. About 60 mg of isoflavones daily reduced serum DHT in healthy young men by only 15%.Even this moderate drop would suggest a reduction in 5-alpha-reductase, which converts testosterone to DHT. However, the markers of 5-alpha-reductase looked at in the study did not show a difference between the treated and the control group.And yet, a combination of capsaicin and soy isoflavones grows hair in both animals and humans. In this study, capsaicin injected into the skin was enough to grow hair in animals, although the combination was more effective. In humans, orally administered isoflavones and capsaicin resulted in hair growth in 88% of the participants with androgenic alopecia, which is a remarkable result for a supplement that reduces DHT by so little.The authors speculated that capsaicin and soy isoflavones promote hair growth by increasing dermal levels of insulin-like growth factor (IGF-1). They suggested that a key factor was calcitonin gene-related peptide (CGRP), which acts as a vasodilator, among other things. It also increases IGF-1 in various tissues, including the skin.This theory is supported by the fact that subcutaneous capsaicin increased CGRP release and IGF-1 expression in hair follicle cells in normal mice but not in CGRP-knockout mice. Soy isoflavones increased the production of CGRP, which explains why the combination was more effective than capsaicin alone.Based on these studies, it was still unclear whether dietary isoflavones alone promote hair growth. Now, the same authors have investigated their idea further. In their new study, they fed isoflavones to mice whose backs were shaved and measured their hair growth (link). Again, both wild-type mice and CGRP-knockout were used.The isoflavone supplement used was Fujiflavone P40, which contains 43.5% isoflavones. 5 g of the product was mixed per each kg of standard chow. On average, the mice ate 4.6 grams of food daily, which means that their daily intake of isoflavones was 0.0046 * 0.005 * 0.435 = ~10 mg (correct me if my calculation is wrong).After three weeks of isoflavone administration, dermal CGRP and IGF-1 levels in wild-type mice increased significantly compared to the control group. In the knockout mice, no difference was seen between mice given isoflavones and the control group.Hair follicle number also increased in wild-type mice given isoflavones. Compared to the control group, they had about 40% more hair follicles. The knockout mice had less hair follicles to begin with, and when they were given isoflavones, no improvement was seen. Thus, it seems that isoflavones grow new hairs through increasing dermal levels of CGRP and IGF-1.Compared to the mice given isoflavones, the control mice seemed to take a longer time growing their existing hair back. Even the knockout mice that saw no increase in IGF-1 grew their hair back quicker when they were given isoflavones. This might be due to other effects of isoflavones, such as reducing DHT levels. Based on the pictures in the full paper, the wild-type mice grew their hair back even quicker, however. Wild-type mice given isoflavones also had a more pronounced darkening of hair than their control group.So what is the take home message? Based on all these studies, it looks like soy isoflavones show very good potential for promoting hair growth. A part of their effectiveness may come from the fact that they reduce serum DHT and increase testosterone, but based on the rodent data, the real kick is from the increase in skin levels of IGF-1.At the moment, there is no data comparing the effectiveness of soy isoflavones vs. capsaicin in humans. However, we do know that the combination is superior in increasing dermal IGF-1 in animals, and that the combination of both taken orally grows hair in humans with androgenic alopecia.For more information on hair growth, see these posts:Topical Retinoids Increase Hair Growth in Most People BioSil, JarroSil & Beer â Silicon Experiment ConclusionZinc Pyrithione Reduces Shedding and Moderately Promotes Hair GrowthHair Growth with Ayurveda â The Nutrich Oil Experiment
- Delicious.com - Svenson Hair TreatmentSvenson is a leading whole at the vanguard in analysis and development of solutions for hair and scalp issues using the most advanced technologies. With over fifty years of trichological experience and data, Svenson offers scientific diagnosis and customized & effective solutions to almost all hair problems. Operating a world network of hair centers these days, there are 54 branches across Asia region, including China, Hong Kong, Singapore, Taiwan, Korea, Indonesia, Brunei, Thailand, and of course, Malaysia.
- Delicious.com - Hair Loss TreatmentSvenson is a leading whole at the vanguard in analysis and development of solutions for hair and scalp issues using the most advanced technologies. With over 50 years of trichological experience and knowledge, Svenson offers scientific diagnosis and customised & effective solutions to virtually all hair problems. Operating a world network of hair centers nowadays, there are 54 branches across Asia region, together with China, Hong Kong, Singapore, Taiwan, Korea, Indonesia, Brunei, Thailand, and of course, Malaysia.
- TheBaldTruth - Propecia Side Effects - Fact Or FictionFear mongering anti-Propecia videos and websites are popping up all over the internet making the decision to effectively treat hair loss even more confusing. Should consumers be legitimately concerned by claims of permanent long term adverse side effects from the drug, or are these videos and websites simply agenda driven anti-Propecia propaganda? IAHRS accepted member [...]
- Delicious.com - Hair TreatmentSvenson is a leading brand at the vanguard in analysis and development of solutions for hair and scalp problems using the foremost advanced technologies. With over fifty years of trichological experience and knowledge, Svenson offers scientific diagnosis and customized & effective solutions to nearly all hair problems. Operating a global network of hair centers today, there are fifty four branches across Asia region, as well as China, Hong Kong, Singapore, Taiwan, Korea, Indonesia, Brunei, Thailand, and of course, Malaysia.
- TheBaldTruth - NeoGraft Warning - A Closer LookLast week, after Alan J. Bauman, M.D. issued a public warning alerting consumers to the fact that unqualified surgeons may soon begin offering âNeoGraft FUEâ procedures to unsuspecting patients, Spencer Kobren took some time to speak with the IAHRS accepted member about the many concerns surrounding this controversial hair [...]